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The primary ICU-BSI and discordant secondary ICU-BSI represent either inadvertent sampling of clinically irrelevant organisms (akin to contaminants) or yet-to-be-determined secondary sources of infection; both have implications regarding antibiotic course duration and risk of recurrence.
The microarray data were cross-checked for inadvertent sampling of inflammatory cells (see Supplemental Table S1 at http://ajp.amjpathol.org ).org
These factors could include inadvertent sampling of nontarget species and sampling of the same species but from populations that have become genetically divergent over many generations.
The occasional isolation of HPAIV (H5N1) from kidney samples (Appendix Table 3) may be explained by inadvertent sampling of overlying air sac wall, which did express influenza virus antigen.
We believe this to be due to an inadvertent sampling bias caused by the inclusion of the nonmodifiable risk factors of gender and age in the CVD risk estimator used.
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We are thus well aware of the omnipresent risk of inadvertent sample and data handling.
Since the total number of entire mtDNA genome sequences per species is much lower than for humans, inadvertent sample mix-up or contamination would be more difficult to spot in the laboratory by comparison with the body of existing data, and consequently, the artificial recombination rate may even be higher.
Freeze/thaw may be the more relevant method of inadvertent sample degradation associated with toxicogenomic studies.
STR typing was performed on all samples to eliminate the possibility of inadvertent sample mix-up or cross contamination.
When coupled with a relatively underpowered sample, inadvertent consequences of adopting ROI approaches are the potential to inflate Type I and Type II error rates due to the possibility of scanning an unrepresentative sample of MDD cases and a failure to include all regions where significant differences may occur across groups or conditions.
This protects staff and samples from inadvertent contamination.
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CEO of Professional Science Editing for Scientists @ prosciediting.com