The FDA found that McKesson responded inadequately and demonstrated a lack of understanding of key regulations, according to a Feb. 7 warning letter.
Add-on lixisenatide once daily in type 2 diabetes inadequately controlled with metformin demonstrated noninferior improvements in HbA1c, with slightly lower mean weight loss, lower incidence of hypoglycemia, and better gastrointestinal tolerability compared with exenatide twice daily.
In conclusion, this head-to-head comparison of dapagliflozin versus glipizide added to metformin in type 2 diabetic patients inadequately controlled with metformin monotherapy demonstrated similar glycemic efficacy at 52 weeks but markedly divergent effects on weight and hypoglycemia.
Even when some women made adequate contact with the health care system during pregnancy they remained inadequately prepared for newborn care also demonstrated in a separate paper [ 41].
While this trial demonstrated reduction of inadequate treatment days, data on outcomes associated with reduced inadequate initial antimicrobial treatment had to be obtained from two other, bigger, studies which involved 1,147 (thereof 316 inadequately treated) medical or surgical ICU patients.
Recent randomized trials of inadequately dosed antibiotics (ceftobiprole and tigecycline) for patients with nosocomial pneumonia have demonstrated greater treatment failures and mortality for the inadequately dosed antibiotics compared to more optimally dosed comparators [ 6- 8].
These results are, again, in agreement with our transcriptome profiling of the ΔrovA mutant and demonstrated that the cell membrane is inadequately constructed in this mutant.
Although studies of the combined treatment have demonstrated benefits, in general, they have been inadequately powered.
While inadequately too low positive end-expiratory pressures (PEEP) have been demonstrated to worsen outcome of patients with ARDS, especially in moderate or severe cases [7], patients without ARDS likely do not benefit from higher PEEP [8].
One consequence of inadequately financed indigent defense is that innocent people go to jail — as demonstrated by the work of the Innocence Project — at a cost of millions of dollars to taxpayers.
As Pennartz et al [ 35] demonstrated in a recent study in type 2 diabetic patients being inadequately controlled with metformin, early use of basal insulin is associated with a significant improvement in residual β-cell function.
