Results of a large observational study of daily practice in >10,000 individuals with type 2 diabetes inadequately controlled on OHAs confirmed the benefits from supplementation of basal insulin treatment with glargine, since the patients demonstrated improved glycemic control with little or no weight gain (36).
This view has since been confirmed by numerous subsequent WHO documents, but remains inadequately implemented at the level of national law and standardised codes of practice despite WHO requests [ 3].
Other surveys conducted in Italy and across Europe [ 10, 14, 15] confirmed these data, showing that pain was experienced in all cancer stages and that it was inadequately managed in a significant percentage of patients, both in early and metastatic stages, ranging between 56% and 82% and it is undertreated in oncology clinics, pain and palliative care and hospice canters [ 16- 18].
GLM has been confirmed to be an effective treatment for patients with RA (including those naïve to MTX, those inadequately responsive to MTX, and those previously treated with a TNF inhibitor), AS, and PsA in phase III clinical trials that have included traditional measures of disease activity and functional decline.
In a recent multicentre, Italian study, Cevoli et al. [29] confirmed that although migraine results in a significant degree of disability, deteriorates the quality of life and has substantial economic costs, most people with migraine do not receive a correct diagnosis and are likely to be inadequately treated.
"Human Rights Watch has documented and continues to document inadequate health care in detention and that situation is just getting worse as the numbers of those detained increase and the facilities are overcrowded and are inadequately staffed," McLemore said, adding that the UCL-Lancet report only confirms what their research has shown in the U.S. for years.
This item had been added to the list, because it was considered to be either lacking from the EFSA report, or inadequately referred to by the hazard 'insufficiently balanced solid food' (HC = 3), again confirming our analysis in Bracke et al. [ 10].
16 This prospective, randomised study confirms previous reports 10 12 13 14 demonstrating that additional IOP lowering may be achieved by switching patients who are inadequately controlled on latanoprost to another PGA and reinforces the concept that changing therapy within the PGA class should be considered prior to adding a second medication if further IOP lowering is required.
In addition, this study confirms other studies which identify that older and less educated adults in society are those who were more likely to consume fruits and vegetables inadequately (6, 12, 15– 17, 27, 28).
This result is similar to those produced in the early model versions that excluded golimumab [ 16, 17] and confirms the results from a real-world study where TNF-α inhibitors were reported to be cost-effective in the treatment of PsA patients inadequately managed with conventional agents [ 55].
