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The report said that inadequate trial preparation, a frequent failure to make timely contact with witnesses and poor presentations at hearings led to case dismissals and damaged the effectiveness of the prosecutions.
The real extent of inadequate trial registration may be under- or overestimated.
Inadequate trial duration and suboptimal dosing are the two most common reasons for low treatment response.
The index should serve to prevent useful drugs from being discarded due to inadequate trial designs.
http://ClinicalTrials.gov has several thousands of trials registered, and consequently the real extent of inadequate trial registration may be under- or overestimated.
In the event that inadequate trial details are reported, study authors will be contacted no more than twice to obtain further information.
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The biggest single issue was that of inadequate trials or inadequate patient numbers in high quality trials.
Thus, investigators who conduct inadequate trials, but who must transparently report, should not be able to pass through the publication process without revelation of their trial's inadequacies.
Considering the criteria in our algorithm (including the causative pathogen), we found that some of the referred cases should have been treated with a 1-stage exchange or a 2-stage exchange a priori, instead of having inadequate trials of debridement with implant retention or 1-stage exchange, respectively.
The Cochrane Review found inadequate trials to investigate AS use beyond 96 h. 9 One RCT (512 patients) compared 3-day with 'between 4-day and 7-day' use and found no significant difference in infusate-related BSI. 12 An unpublished conference abstract reported another RCT of 769 patients with AS replaced at 72 or 120 h, with no between-group differences in catheter colonisation or VAD-BSI.
When RCTs are utilized, they often suffer from poor trial design, inadequate statistical analysis, and incomplete reporting.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com