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This data suggest an inadequate release of this hormone, which could be responsible for decreasing its protective role against pain, via several mechanisms described above.
It can be inferred that PTX-mPEG-PCHLG-Nps could probably have higher anticancer efficacy due to the inadequate release of PTX from nanoparticles.
Deficiencies in coagulation inhibitors such as heparin cofactor II and antithrombin III, inadequate release of plasminogen activators and uncontrolled production of plasminogen activation inhibitors are few pathophysiological conditions that could lead to the formation of blood clots (Gallimore and Friberger 1991) inside the blood vessels, clinically known as thrombosis.
Inadequate release of brain natriuretic peptide has been proposed as a contributing mechanism in CSW [ 77].
However, these beads are usually not as effective as the commercial beads because of inadequate release kinetics.
This again could reflect either poor tumour penetration by the liposomes or inadequate release of free drug (Meerum Terwogt et al, 2002).
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Submitted to a preliminary in vivo biological evaluation, a similar oxamniquine profile was observed to the monomeric forms although an inadequate drug release may be responsible for the methacrylic copolymer failure.
However, the putative protease cleavable sequences tested were inadequate for release of R9-rGel from CPE-E9-G4S-R9-rGel.
Even though many other immune cells, including effectors of innate immunity, are major sources of these molecules, it has been shown that inadequate cytokine release by CTL was sufficient to induce severe consequences following viral infections 47.
At the end of the study, all mice with β-hydroxybutyrate levels >1 nmol/L were receiving the lower insulin dose of 0.05 U/day and had very low serum insulin levels associated with high blood glucose levels; this observation suggests that the higher β-hydroxybutyrate levels were due to inadequate insulin release from the micro-osmotic pumps in these particular mice.
A number of barriers to intervention adoption have been cited including: a lack of financial resources for planning, training, and teacher release; inadequate levels of professional development; inadequate program resources; failure to adopt a 'whole of school' approach to implementation and monitoring; and inadequate support by school executives [ 31].
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CEO of Professional Science Editing for Scientists @ prosciediting.com