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However, some disadvantages, such as high cost, inadequate reactivity, fabric yellowing, excessive fabric tendering and toxicity, were observed with these substances, preventing their industrial application.
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Moreover, concomitant type 2 diabetes increases the risk of high on-aspirin platelet reactivity (HPR), defined as inadequate inhibition of platelet function [ 4].
Concomitant DM2 also increases the risk of high on-aspirin platelet reactivity (HAPR), defined as inadequate inhibition of platelet function, assessed in vitro with laboratory tests [ 3– 9].
Interesting are the significant species differences between rodent and human FcRn reactivity, rendering wild type rodents an inadequate model for studying IgG serum half-life.
Under prasugrel, persistent platelet reactivity was found in 20%% of samples with inadequate effect using flow cytometry, in 10 % using light transmission aggregometry with adenosine diphosphate and in 40%% using the PFA-100® system with collagen adenosine diphosphate.
These incidents are often the result of inadequate pressure relief system designs due to a limited knowledge of the chemical reactivity hazard.
This suggests that an inadequate expression of CD1d [ 33] or an aberrant presentation of the natural NKT cell antigen, but not decreased reactivity, might account for the NKT cell reduction in these responder patients.
Diabetic individuals are characterized by increased platelet reactivity and an increased level and activity of prothrombotic clotting factors (4), which may explain their predisposition to inadequate aspirin-induced effects.
"Instant reactivity always favours the familiar.
Inadequate, inadequate, inadequate.
But this surface reactivity may come at a price.
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CEO of Professional Science Editing for Scientists @ prosciediting.com