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The lack of associations in a large proportion of genes can also be attributed to inadequate marker coverage on the Affymetrix 500 k chip.
In conclusion, the lack of associations in BP candidate genes may be attributed to inadequate marker coverage on the genome-wide arrays, small phenotypic effects of the loci and/or complex interaction with life-style and metabolic parameters.
Serum creatinine is an inadequate marker for AKI [ 25].
Therefore, the ECWBIA/TBWBIA ratio appears to be an inadequate marker of the volume status [ 7].
This incomplete linkage was a consequence of inadequate marker density; therefore, we explored the effect of increasing the marker density.
Only a minority of panelists recommended switching to intensifying chemotherapy in patients with an inadequate marker decline [ 37, 38].
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Moreover, relying on inadequate markers could lead to incorrect conclusions about a target cell type, as experimental results based upon isolates supposedly containing only the pure target populations could be affected by the unbeknownst presence of other cell types.
Patients with an inadequate tumor marker decline should continue to complete first-line treatment (supplementary material S14, available at Annals of Oncology online).
The reasons for these false-positive signals could include inadequate surrogate markers, changes in dose, changes in usual care, changes in inclusion criteria and settings and/or the play of chance between the POP/Phase II and pivotal/Phase III RCTs.
However, the use of inadequate serological markers may underestimate exposure by virtue of their lack of sensitivity.
The 16 S rRNA genes of strains isolated from different bee species are nearly identical in sequence and therefore inadequate as markers for studies of coevolutionary patterns.
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