We suggest that the major limitation of the carrier-ESO formulations described in this report was inadequate carrier functionality, and not a lack of intrinsic potency of the ESO.
While directed differentiation and transcription factor-mediated conversion strategies have generated progenitor cells with multilineage potential, to date, therapy-grade engineered HSCs remain elusive due to insufficient long-term self-renewal and inadequate differentiated progeny functionality.
Heterogeneity is reported in the particle size, charge, and composition of high density lipoprotein, and therefore level alone may be deemed an inadequate marker for functionality.
Though single quality layer codestreams may be adequate for the basic requirements of applications, this default layer allocation may become inadequate when extended functionalities are required.
Firstly the prototype simulator used was inadequate, in terms of functionality, to meet the training requirements for teaching anesthesiologists, novice in UGRA.
Among these, almost a third of providers (33 %) reported inadequate equipment in numbers and functionality as a main reason for patient referral.
Thus, passive restoration or self-recovery of mangroves was considered inadequate in these circumstances for regaining natural ecological functionality.
As a result, they may be inadequate to ensure life safety, let alone continued functionality during and after a severe natural hazard.
Some icons, functionalities and modules possess names that are inadequate.
