The outstanding 13C sensitivity of this probe allowed us to directly determine the 13C connectivity on 1.1 mg of natural abundance histidine using an INADEQUATE experiment.
The INADEQUATE experiment was recorded on a Bruker Avance III 700 MHz NMR spectrometer using a 5 mm TCI cryogenically cooled probe.
1H or 13C polarization is used a starting point in long-range correlation 1H-detected IPAP DEPT-INADEQUATE or RINEPT-INADEQUATE experiments.
Apart from outright fraud, there are all those "benevolent mistakes" that scientists make more or less unwittingly: poor experiment design, sloppy data management, bias in the interpretation of facts and inadequate communication of results and methods.
According to the panel, several flaws--including poor experimental design, uncertainty about the chemical composition of the potatoes fed to the rats, the small number of rats studied, and poor statistical analysis--make the data in Pusztai's experiments "inadequate".
Estimation of all parameters values may not be possible when unsatisfactory quantity and/or quality of experimental data are available or when bad model structure and/or inadequate design of experiments were built, leading to nonsignificant or high-correlated parameters with influence on model prediction.
Assignments were made via H NMR, C NMR, heteronuclear multiple quantum coherence (HMQC), heteronuclear multiple-bond correlation (HMBC), N HMBC, HH correlation spectroscopy (HH COSY), nuclear Overhauser effect (NOE), and incredible natural abundance double-quantum transfer experiment (INADEQUATE) spectra.
When two or more factors are known to act together as independent variables, one-factor-at-a-time experiments are inadequate.
The simulations predict that although an undercooled zone forms ahead of the growing columnar front, thermal conditions in the diffusion-controlled experiments were inadequate to trigger an entirely equiaxed zone without grain refiners.
