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Ongoing oxidative stress resulting from inadequate dosage of the compound may account for this result [ 3].
Indiscriminate use and inadequate dosage of conventional antibiotics have contributed to the development of resistant bacterial strains, decreasing the therapeutic options [ 1].
The present study seems to suggest inadequate dosage as one of the possible mechanisms for the higher failure rate of enoxaparin in ICU patients.
The study seems to suggest inadequate dosage as one of the possible mechanisms for the higher failure rate of enoxaparin in ICU patients.
The divergence from guidelines was mostly noted for patients with hypomania, which was associated with inappropriate treatments with antidepressants, absence of psychotropic treatment, and/or inadequate dosage [ 20].
The benefit of administering the right drug is often nullified by suboptimal drug exposure at the infection site due to inadequate dosage.
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The inadequate dosages weakened any likelihood of establishing onset for any specific drug treatment.
Pediatric patients are reported to receive less analgesia than adults with similar diagnoses or surgical procedures, and to be prescribed inadequate dosages of analgesic at discharge [ 6, 7].
Where a dose-response relationship exists, meta-regression within an MTC can potentially overcome issues where RCTs have used potentially inadequate dosages.
Many studies support the correlation between deficient drug prescribing and poor adherence to evidence based treatment guidelines, inadequate individual dosage adjustments and adverse drug events [ 3- 5].
In addition, data from several studies showed that 30-day mortality rates and costs of care increased significantly when empirical therapy was delayed or inadequate (inappropriate dosage, resistant isolate) [ 20- 24].
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com