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Inadequate binding of aPC to EPCR could explain the absence of the anti-inflammatory effect and be responsible for the persistence of monocyte TF expression.
There are numerous potential reasons for this lack of reaction, including inadequate binding of the allergen to the IgE antibody, insufficient dose, and digestive instability of the allergen.
The interaction with AC1-C1b requires binding of Ca2+ to one EF-hand in each lobe of CaM, which can explain the complex of AC1-C1b with 2 mol of Ca2+-bound CaM observed in the ESI-MS experiment but the inadequate binding of GST-1C1b with the CaM mutants.
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In addition to that, there also is a possibility of inadequately functioning ski-binding-boot (SSB) system resulting from a inadequate high binding release values.
The reasons need to be understood, but it may simply be inadequate prior binding data in some cases.
With regard to mAbs, lack of specificity to the target antigen might result in cytotoxic effects on healthy tissue, whereas poor internalization or inadequate antigen-binding affects the therapeutic effect of the ADC.
A notable case where PWMs appear to be severely inadequate is the binding affinity of nucleosomes.
When telomeres become short enough to produce inadequate telomeric protein binding or t-loop packaging they generate a DNA damage signal, which causes the growth arrest known as senescence or replicative aging [ 8].
Acknowledging that, the trio of finance ministers criticised the Juncker proposal as inadequate and called for binding new rules.
In most cases, SUMO formed complexes seems to result in regions that extend beyond a single TFBS, therefore rendering traditional peak calling methods inadequate when studying the binding sites for SUMOylation within long regions.
This demands that governments recognize that the state has a key role in helping private enterprise by working to establish the infrastructure necessary for economic development, especially on a continent dealing with the binding constraints of inadequate transport and electricity production.
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CEO of Professional Science Editing for Scientists @ prosciediting.com