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In this sense, on the one hand, underload may lead to inadequate activation and scarce use of workers' available resources.
In this context, we propose that the cross-presentation deficiency in ΔY mice results in T cells receiving inadequate activation signals which do not clonally expand and instead undergo apoptosis with the manifestation of a large reduction in CD8 T cell number at the peak of Listeria infection response.
Collectively, these results demonstrate that Irs2 null mice display inadequate activation of postsynaptic NMDARs.
This implicates inadequate activation of PPARα with the western diet in the development of cardiac dysfunction.
It is known that a high level of MMPs expression can lead to inadequate activation of the macrophages [ 37].
Importantly, we show that NSCLC TICs exhibited inadequate activation of DDR signaling, impaired checkpoint arrest and a significantly attenuated apoptotic response.
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Fatigue may also promote extreme lower biomechanics stemming from inadequate active joint stabilization via a suboptimal muscle activation strategy [ 20, 21].
However, current vaccine approaches have shown only limited success in patients with cancer because of inadequate immune activation.
This condition arises from inadequate antecedent activation of frontoparietal and cingulate cortical regions involved in decision-making and implementation processes related to micturition control.
However, insults which initiate necrosis cause PARP-1 overactivation that proceeds unchecked due to inadequate caspase activation [ 82- 84], lower PARP-1 cleavage and less PARP-1 24-kD fragment formation.
Therefore, if any participants had coccidioidomycosis that did not resolve because of a T h 2 immune response, we may not have been able to detect the infection because of inadequate lymphocyte activation (i.e., a false-negative test result) (9 ).
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