For the majority of GPCRs, an intracellular versus plasma membrane distinction may 'simply' reflect the detection of mature GPCRs in the endocytic pathway and/or immature GPCR pools (presumably functionally inactive) yet to be presented to the plasma membrane.
Nearly half those with disabilities of working age are economically inactive, yet 1.2 million economically inactive disabled people say they want to work.
Such "bivalent" genes are thought to be transcriptionally inactive, yet poised for imminent activation.
Often, genes that move away from the lamina are concomitantly activated; many others, however, remain inactive yet become unlocked for activation in a next differentiation step.
The major roles of graphene are highlighted as (1) a superior active material, (2) ultrathin 2D flexible support, and (3) an inactive yet electrically conductive additive.
Many render BRAF catalytically inactive, yet increase the MEK phosphorylation through transactivation of CRAF (Garnett et al, 2005).
This specificity is important, because some between-method variability is believed to result from biologically-inactive, yet immunologically cross-reactive components present in patient plasma [ 34].
There was even (if somewhat inactive at present) a Krays Supporters' Club.
If some inactive element is present in the same proportions, we are not able to detect it.
Yet the present puzzle persists.
Yet it presents challenges too.
