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Tectonic units (regions that once formed or now form part of a single tectonic plate and whose structures derive from the formation and motion of that plate) that are defined on the basis of active structures in Asia are not identical to those defined on the basis of its fossil (i.e., now inactive) structures.
Likely causes are the poor representation of the inactive structures containing these motifs.
The SSC displays active and inactive structures separately at each step of the refinement.
Significantly, the biologically active and inactive structures determined experimentally matched well the structures predominant in each computational set.
Some features have an experimental signal with a bias towards inactive structures (<0.5), however the model remains accurate in most cases.
In addition, we produced a model of the structure of the TSHR TMD in its inactive conformation based on 16 GPCR inactive structures.
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To select for agonists, we only considered molecules with higher ranking in the active structure than the inactive structure, as this would reflect the structural bias we found in the active structure.
ASK1 forms an inactive structure with reduced Trx.
The structures of 16 GPCRs in an inactive state were used as templates to build an inactive structure of the TSHR TMD (TMD_I) (Table 1).
In the hairpin-DNAzyme probe, the HRP-DNAzyme sequence is protected in a "caged" inactive structure, whereas the loop region includes the target complementary sequence.
The inactive structure reveals a mechanism of inhibition in which the N-terminal FERM domain directly binds the kinase domain, blocking access to the catalytic cleft and protecting the FAK activation loop from Src phosphorylation.
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