Sentence examples for inactive sequence from inspiring English sources

The engineering of completely novel catalytic activity requires traversing inactive sequence space in a fitness landscape, a feat that is better suited to computational design.

DDC excludes inactive sequence (i.e., disease progression at the first tumor evaluation) and intervals between disease progression and re-initiation of treatment (either reintroduction in the stop-and-go strategy or subsequent course of treatment in the planned multi-line strategy).

Directed evolution experiments, which probe the sequence space of a protein through mutations in search for an improved variant, frequently result in such inactive sequences.

Perhaps this is because seven of the nine inactive sequences containing U89 have a pyrimidine at position 87.

Folded into the protein sequence databases, these inactive sequences may corrupt future genome annotations and protein-structure function analyses that rely on comparative sequence analysis.

Conditional deletion of the centromeres of chromosome Z or 5 led to neocentromere formation at a frequency of ∼3 × 10−6 on a wide range of both transcriptionally active and inactive sequences (Shang et al., 2013).

In either case, communities of promiscuous ribozymes may increase against the odds of extinction due to local demographic stochasticity when catalytically active replicators are scarce – i.e., in the initial state dominated by random, mostly catalytically inactive sequences.

This analysis corresponded to the transfection of cells with a series of mutants of −252/+38Luc where a stretch of 20 bases was exchanged for a transcriptionnaly-inactive sequence successively along the whole region [36].

Indeed, we found that purified USP13 is inactive despite sequence homology to USP5, a constitutively active isopeptidase.

These yeast cells were simultaneously co-transfected with the inactive complete sequence or catalytic domain of LmjMCA.

The third glutamic acid residue within the conserved "PIE" motif mutated to an N in the apparently inactive Submariner_Ac1 sequence, and the first aspartic acid residue within the conserved "DET" motif mutated to an N in the apparently inactive Submariner_Ac2 sequence (Fig.  3a).