The possible existence of such inactive routes for metabolizing fatty acids without the use of ICL in MTB has been discussed elsewhere [ 39] and, if true, would imply that MTB could rapidly evolve resistance to drugs inhibiting ICL.
Route entries expire after a specified time if the route becomes inactive (i.e., it is not used for data transmission).
It is recognized that an ideal anti-cocaine treatment is to accelerate cocaine metabolism by producing biologically inactive metabolites via a route similar to the primary cocaine-metabolizing pathway, i.e., butyrylcholinesterase (BChE -catalyzed hydrolysis of cocaine.
It can be argued that an ideal anti-cocaine medication would be one that accelerates cocaine metabolism producing biologically inactive metabolites via a route similar to the primary cocaine-metabolizing pathway, i.e., hydrolysis catalyzed by butyrylcholinesterase (BChE) in plasma.
Three compounds were inactive by the oral route in the doses tested.
Both these metabolic routes yield inactive, non-toxic final products.
To this purpose, first, this node completes the reservation process within the active duration and second, it receives data from the previous node and forwards it to the next node in the route during the inactive duration.
Many of Hosmer's 1,200 active and inactive customers, stretched across 20 routes, are buying the company's line of diet sodas, or they're buying none at all.
Furthermore, studies in rodents have found that neonates have limited ability to convert BPA into an inactive conjugated form, independent of the route of administration (Taylor et al. 2008).
For comparative purposes, 5′-homoadenosine was made available by a newly designed route and found to be inactive.
The decrease was not due to conversion of 35S-proinsulin into insulin because this customary route for nascent proinsulin is inactive during this limited chase course [15], [26].
