Consequently, it remains entirely unknown if hypo-phosphorylated Rb contains one, two, three, five, seven or more phosphates and at what phosphate number does the putative hypo-phosphorylated Rb become inactive to release E2F transcription factors.
This intradimer rearrangement overcomes the relatively weak CC1-SOAR/CAD interactions that hold STIM in an inactive conformation, releasing the SOAR/CAD domain to activate ORAI channels.
The binding of cAMP to the protein kinase A (PKA) regulatory subunit KIN-2 dissociates it from the inactive holoenzyme, releasing the PKA catalytic subunit, KIN-1.
Inactive Cu can release the volume expansion of Sn, prevent Sn from aggregation, and accommodate structural stress.
Finally, TG-2 can release inactive precursors of molecules that remodel the matrix sequestered in the matrix [9], [10].
This activation step requires the inactive Rab to release GDP and bind GTP, a process triggered by a specific guanine nucleotide exchange factor (GEF) [ 14].
Cancer cells release inactive proMMP-2 which can be activated by free radicals, such as produced by the radiolysis of water (Saari et al, 1992; Paquette et al, 2003).
TransCon growth hormone (GH) is a sustained-release inactive prodrug consisting of unmodified GH transiently bound to an inert carrier molecule designed to release fully active GH over a one-week period.
In the presence of trypsin, hemoglobin would be hydrolyzed to small peptides, releasing inactive hemin molecules.Hemin has slight effect on the fluorescent intensity of NAC-CdTe QDs, so the combination of hemoglobin and NAC-CdTe QDs would be dissociated, leading to the fluorescence recovery of NAC-CdTe QDs.
Once inactivated inside the cell, the inactive product is released into the extracellular space.
When AKT is inactive, Foxo3a is released from the cytoplasm and it goes back to the nucleus, where it promotes apoptosis.
