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We used the binary bioactivity outcome annotations, e.g. active versus inactive, provided in the dataset submissions as the corresponding activities.
In addition, the PubChem bioactivity outcome annotations (i.e., active or inactive) provided by depositors were directly used to obtain the bioactivity potency differences.
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Several mutants of the GCN4 leucine zipper are catalytically inactive, providing important negative controls and unequivocally associating the enzymatic activity with the peptide under study.
The identified action of neuroglobin in rendering cytochrome c apoptotically inactive provides a unique biological platform on which we can base the design of targeted therapies against a number of neural diseases.
Interestingly, the rather linear 4-cyanosubstituted compound 1s (IC50 = 50 μM, entry 19) had encouraging activity, while the bulkier 4-methylsubstituted analog 1t (entry 20) was inactive, providing further evidence for a rather small and linear binding pocket of ATGL.
All of the performed experiments indicated that random selection of inactives provided better results than the diverse approach.
Dr. Brendan Wren, who studies gut-infecting bacteria at the London School of Hygiene and Tropical Medicine, said the inactive genes provided a useful list of what a bacterium requires to colonize the gut.
Comparisons of active and inactive compounds provided preliminary structure-activity relationship information.
For example, 2.2% of economically inactive women provide 20 to 49 hours unpaid care - for economically active women, that figure only falls to 1.6%.
When the frame moves toward its equilibrium position, the device becomes inactive and provides no obstacle to the movement of the structure.
Correlation of the results of metal (Mg2+ and Mn2+) titration studies with HIV IN inhibition for a series of active and inactive compounds provides support for the model.
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