Some protein processing events may be included when they are required to form an active form of a product from an inactive precursor form.
Chemerin circulates as an inactive precursor (chem163S), and its activation requires proteolytic cleavages at its C terminus, involving proteases involved in coagulation, fibrinolysis, and inflammation.
Total AMH consists of proAMH (inactive precursor) and AMHN,C (receptor-competent), but neither isoform has been tested individually for their ability to predict PCOS diagnosis.
As further support for the model, attempts to dock bigET, an inactive precursor to endothelin that does not bind to the receptor, found no sites for tight binding.
Plasmin exists in milk in both its active form as well as its inactive precursor plasminogen.
Biologically active, mature IL-1 beta (mIL-1 beta) is released from activated monocytes after proteolytic processing from an inactive precursor (pIL-1 beta).
Caspase-1 is able to cleave the inactive precursor pro-IL-1β to form the active cytokine IL-1β.
Brain, as other tissues, possesses the enzymes necessary for local formation of active hormones, neurosteroids, from inactive precursor hormones.
It is prepared by chemical modification of 10-deacetylbacattin III, an inactive precursor compound, and then isolated [2].
One unknown link in the activation of NF-κB was the ubiquitin ligase that catalyzes generation of the active p50 subunit from its p105 inactive precursor.
It has also been confirmed that the pheromone was formed by isoprenylation of an inactive precursor peptide (Schneider et al. 2002).
