However, tumor cells have commonly inactive mechanisms of apoptosis induction and constitutively active PI3-K pathway, being responsible for cell growth and proliferation.
S177D and S177E site-directed mutants are inactive, suggesting a mechanism for post-translational control of metabolic flux through the F. tularensis MEP pathway.
By this mechanism inactive genes in embryonic stem cells [ 21] and CD4+ T cells [ 8, 22] are kept poised for activation when needed upon differentiation.
The potent effects we see on nongenomic signaling mechanisms could explain why concentrations previously determined to be inactive via genomic mechanisms still have toxic and teratogenic effects on wildlife (Brucker-Davis et al. 2001).
By contrast, ubiquitin-conjugated USP7cd structures demonstrate the canonical cysteine protease active-site geometry; however, the structural features of the USP7cd that stabilize the inactive conformation and the mechanism of transition between inactive and active states remain unclear.
The current study was designed to shed light on the question whether the multiple X chromosomes in testicular germ cell tumor are active or inactive through a complex mechanism of X chromosomal gain and XIST expression.
The inactive structure reveals a mechanism of inhibition in which the N-terminal FERM domain directly binds the kinase domain, blocking access to the catalytic cleft and protecting the FAK activation loop from Src phosphorylation.
Most often, this mechanism yields inactive retropseudogenes; for example, because of the lack of promoter elements necessary for expression.
Thus, evaluation of MMP-9 may suggest prior existence of TA even in inactive patients, although the mechanism of this elevation is a matter of further investigation.
Thank you for submitting your work entitled "Two-Subunit DNA Escort Mechanism and Inactive Subunit Bypass in an Ultra-Fast Ring ATPase" for peer review at eLife.
We propose that the aggregated form of mutant p53 may act as a sink, sequestrating the native protein into the inactive conformation through a mechanism described for a typical prionoid [ 63, 64].
