Sentence examples for inactive lactone from inspiring English sources

Simvastatin is a lipophilic compound administered as an inactive lactone prodrug.

HPLC confirmed that while commercial lovastatin existed primarily in a biologically inactive lactone (L) form, the biologically active hydroxyacid or H-form predominated in FRSE.

Lovastatin and simvastatin, for example, circulate as an inactive, lactone prodrug [13], while atorvastatin and rosuvastatin are biologically active as calcium salts [14, 15].

It undergoes rapid glucuronidation by a series of enzymes and is then converted to its inactive lactone form by elimination of glucuronic acid.

Statins share an HMG-like moiety, which may be present in the form of an inactive lactone form that acts a prodrug, and in addition they also have a rigid hydrophobic substituted decalin ring covalently bound to the HMG-like moiety.

E. lenta is also known to harbour a cardiac glycoside reductase operon, which can reduce digoxin, to its more inactive reduced lactone dihydrodigoxin [ 45].

7 Pitavastatin is rapidly metabolized primarily via hepatic glucuronidation with UDP glucuronyltransferase (UGT1A3 and UGT2B7), forming the major inactive metabolite – pitavastatin lactone – with minimal CYP2C9 and 2C8 metabolism of clinical concern.

Both substances have a pH-dependent equilibrium between their active lactone and inactive carboxylate forms.

Irinotecan is a highly effective anticancer drug which displays a pH dependent equilibrium between its active lactone and inactive carboxylate forms, with rapid conversion to the carboxylate form occurring at a neutral pH.

In contrast to the progressive trapping of topoisomerase I with topotecan exposure, detection of the intracellular topotecan levels (both active lactone and inactive hydroxy acid forms) by flow cytometry revealed that the topotecan (10  μ M) rapidly entered cells, and the maximal topotecan concentration was achieved within 10 min.

The tested aglains and rocaglate β-lactones were inactive.