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The CSR incorporates EPD, based on estimates of TTP, in the stage I decision-making process to provide an early signal of drug inactivity and allow for early termination of an inactive agent.
For this to be translated into the clinic the active agent would have to be purified to separate it from the inactive agent.
In all instances, inappropriate therapy occurred not because of the use of an in vitro inactive agent but because of a delay in the initiation of antibiotics.
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This contrasts with current street supplies of ecstasy and speed, which are often very low quality after being cut with inactive agents and may even contain some other, more dangerous, drugs such as methylamphetamine.
In the introduction to "America's Black Past," an anthology published in 1970, the historian Eric Foner wrote that, among this country's "myths and misconceptions, one of the most pervasive and pernicious . . . is the picture of blacks as inactive agents in history".
Completely inactive agents are not included in the ni counts.
Prodrugs are biologically inactive agents that upon biotransformation in vivo result in active drug molecules.
For example, a randomized trial of just 100 patients could lead to the termination of development of 90% of inactive agents whereas at least 80% of agents with a meaningful and realistic increase in progression-free survival would be identified for confirmatory study.
On the contrary, only 46% of NTP HTS "inactive" agents are classified by the CPDB as noncarcinogenic in rodents.
So, other evidence suggesting the plausibility of inactive agents as treatments for prostate cancer (though not necessarily HRPCA) was usually found.
One of the frequently referenced articles in sarcoma, by Van Glabbeke et al, estimated the progression-free rate (PFR) for active and inactive agents for STS in the first-and second-line setting based on the EORTC clinical trials database.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com