Open state fast inactivation time constants are shown for WT and A1273V channels in Fig. 4c,d, respectively.
This model allows designing the CFI according to the inactivation time and the chosen design approach.
However, the inactivation time constant τ at −60 mV and at saturating pressure was approximately four times slower than the mouse and human orthologues.
Open-state fast inactivation time constants are plotted versus voltage for WT and A1273V NaV1.1 at 37 °C (a) and 40 °C (b).
Network behavior was simulated for different combinations of T-type calcium channel conductance, inactivation time, steady state activation/inactivation shift, and cortical GABAA conductance.
The double-pulse protocol used to measure fast inactivation recovery is shown in the inset of a. Source data for fast inactivation time constants can be found in Supplementary Tables S4 and S5.
Mechanical stimulation of PIEZO1 via pressure, cell poking, or substrate deflection at negative potentials show fast current inactivation5,12,18,28,31, and here we also measured fast inactivation time constants (τinact = 60.9 ± 3 ms, eight cells).
X-ray photoelectron spectroscopy (XPS) was used to determine the surface atomic concentration of O, Ag, C and N for the DC- and DCP samples as a function of the bacterial inactivation time.
Attenuated total reflection Fourier-transform infrared (ATR-FTIR) spectroscopy was used to monitor the changes in the functional groups leading to bacterial inactivation as a function of the bacterial inactivation time.
We investigated a lambda exonuclease treatment of a PCR amplified dsDNA target to produce ssDNA with regard to probe-target position, treatment duration and inactivation time towards its impact on fluorescence or electrical signals on two DNA-chip formats.
The minimum residence time (MRT) approach guarantees a residence time for all molecules entering the continuous viral inactivation of at least the inactivation time of the batch inactivation step.
