Sentence examples for inactivation of key from inspiring English sources

Previous studies have shown that glucocorticoids can cause inactivation of key members of the translational machinery in muscle cells [21] and compromise protein synthesis in skeletal muscle [22].

The mitochondrial membrane damage can also generate the inactivation of key transporters involved in ion homeostasis.

The inactivation of key proteins can have serious consequences in the vital metabolic pathways.

Inactivation of key cancer cell survival specific to these processes might enhance the efficacy of anticancer drug treatment.

The loss or attenuation of pathogenicity in several Listeria sensu strictu strains and species results from the loss or inactivation of key pathogenicity genes.

The mechanisms of ATO-mediated tumor cell responses include inactivation of key proliferation and survival pathways including the hedgehog, MAP kinase, NfκB and PI3K/AKT signaling pathways [ 5].

However, frequent mutations in and subsequent functional inactivations of key regulators of cell cycle progression, such as p53, p21 or p16, confer tumor cells with the ability to bypass senescence, leading to oncogenic transformation.

Systematic knockout (inactivation) studies of key imprinted genes, especially as performed on mice, have provided support for the hypothesis that imprinted genes that allow expression of paternally inherited alleles tend to drive more extraction of nutrients from the mother during gestation and after birth to produce a larger child.

We show here, by targeted inactivation of this key cohesin component in mice, that Rad21 is a DNA-damage response gene that markedly affects animal and cell survival.

The inactivation of a key enzyme of the citric acid and glyoxylate cycles make it plausible why the transposon insertion in mqoB reduced bacterial fitness to persist and grow in vivo.

This can be achieved by the phosphorylation-mediated inactivation of a key translation initiation factor, eukaryotic initiation factor 2 (eIF2).