Sentence examples for inactivate expression from inspiring English sources

Regulation of phase variation can occur through multiple, different mechanisms, including homologous and site-specific recombination events that generate chromosomal changes that activate or inactivate expression of a gene [ 1], e.g., due to inversion of a promoter element.

ABCB1 analysis and characterization of CpG islands of the ABC loci suggest aberrant DNA methylation as a plausible mechanism inactivating expression of the ABC transporter genes in PCa.

Construction of the Plasmid to Inactivate Genome Expression of WhIP Protein Expression To study if the whip gene product could function in origin firing, it was essential to generate a mutant with complete whip gene sequence which lacks WhIP protein expression.

The advanced carcinomas inactivate MALT1 expression by the promoter methylation, and the loss of expression worse the patient prognosis (Chiba et al, 2009).

Many IS elements have been shown to activate or inactivate the expression of neighboring genes.

These data indicate that novel miRNAs can be readily produced in vivo and can be designed to specifically inactivate the expression of selected target genes in human cells.

We used an inducible Cre-LoxP system to selectively inactivate Lmx1b expression in the raphe nuclei of adult mice.

In the present study, we took advantage of an inducible Cre-LoxP system to inactivate Lmx1b expression in adult 5-HTergic neurons.

To test this hypothesis, we used a tamoxifen-inducible Cre-LoxP system [13] to selectively inactivate Lmx1b expression in central 5-HTergic neurons of adult mice.

To specifically inactivate Lmx1b expression in 5-HTergic neurons in the adult mouse brain, Lmx1bflox/flox mice were crossed with Pet1-CreERT2 mice (see below) and their offspring Pet1-CreERT2; Lmx1bflox/+ mice were then crossed with one another to obtain Pet1-CreERT2; Lmiceflox/flox (Lmice iCKO) mice.

Namely, deletion of R genes is known to inactivate the expression of a large number of genes, consequently, deletion mutants of the R genes (ΔlasR, ΔrhlR, and SB) have a large metabolic advantage over the WT [8], so they constitute an overwhelming majority of the co-swarming populations at 24 hours (Figure 2, panels 4 6).