Sentence examples for inactivate by from inspiring English sources

In fact, since the signalling function of HER3 is mediated through its role as a substrate of HER2 and a scaffold for recruitment of signalling proteins, it presents a difficult target to inactivate by current pharmaceutical approaches.

Sasazawa et al (2009) suggested that BMA, a potent functional suppressor of Bcl-xL, functions not as a small molecule that can inactivate by recognising the surface pocket of Bcl-xL but rather as a modulator of cellular pH which induces the alternation between pro- and anti-apoptotic protein function.

DNaseI was inactivated by vortexing (30″) and heat-inactivation (10', 65°C).

Bacterial quorum-sensing signals are inactivated by mammalian cells.

In contrast, INH is inactivated by arylamine N-acetyltransferases (NATs).

Unfortunately, the enzyme is rapidly inactivated by the oxidative environment.

The reaction was inactivated by incubation at 90 °C for 10 minutes.

The flsQ1 gene was inactivated by PCR-targeting method using the apramycin resistance cassette8.

Many structural and regulatory proteins are inactivated by caspases, while other substrates can be activated.

FVII gene can be inactivated by disrupting the entire coding sequence for the mature FVII protein29,30.

TFEB is phosphorylated and thus inactivated by BRAFV600E via its downstream ERK independently of mTORC1.