We present a simple method, called fluorescence-based assessment of plasma-induced hydrophilicity (FAPH), that enables spatial mapping of the local hydrophilicity of surfaces normally inaccessible by traditional contact angle measurement techniques.
Despite the lower level of external validity, laboratory studies can be a valuable substitute for randomized field experiments and provide insightful new angles to research topics inaccessible through "traditional" empirical methods.
At a similar position to G211, SNM1A and Apollo have G882 and G185, which are solvent inaccessible and have positive ϕ torsion angles; therefore, G211V is likely to disrupt the local conformation around the residue.
The details of such form factor scattering are frequently inaccessible, as the scattering occurs at very low angles.
In this framework, there could be 64 distinct environments for a residue from the combination of structural features: four from secondary structures (α-helix, β-strand, coil and residue with positive φ main-chain torsion angle), two from solvent accessibility (accessible and inaccessible), and eight (23) from hydrogen bonds to main-chain carbonyl (CO) or amide (NH) or to another side chain.
Although it is sufficiently accessible to be important for the binding of non-peptide antagonists to the CGRP receptor (ter Haar et al., 2010; Miller et al., 2010), this change of angle is likely to make it particularly inaccessible to any peptide orientated parallel to the main axis of the CLR N-terminal helix.
Implementations of magic angle field rotation are extremely demanding due to power requirements or an inaccessible geometry.
Because of this decreased tilt angle and the benzyl ester moieties being bulkier than the ethyl groups in 5, the central phenyl group is inaccessible for CH···π interactions.
Plug inaccessible behind refrigerator.
It's completely inaccessible.
