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Given the Premier League clubs' inability to progress to the latter stages of the Champions League, it is interesting to note the significant sums being spent on defenders.
Too many times in my job, I hear staff discussing a child's inability to progress and putting it down to where they are from, their personality and that they are unteachable.
Records provided to The A.P. by Mr. Miera's family show that he was released on parole from a Texas Youth Commission facility in May 2005 and discharged entirely four months later for "inability to progress due to mental illness/retardation".
To some, such as New York magazine's John Heilemann, the primary cause for this has been Obama's inability to progress from campaign mode to governing mode.
While Shenmue was lauded for its innovation, visuals and music, its critical reception was mixed; points of criticism included "invisible walls" which limited the player's sense of freedom, boredom caused by the inability to progress without waiting for events scheduled to occur at specific times, excessive in-game cutscenes and a lack of challenge.
Inhibition of mTOR likewise affects the cell cycle, with a down-regulation of cyclin D and the inability to progress from G1 to S-phase [ 5].
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Very intriguingly, pMcm2 in AD neurons, unlike in most cancer cell lines [ 42], appears to accumulate mostly in the cytoplasm suggesting further degree of deregulation of the MCM complex in disease tissues that may explain the inability of neurons to progress through cytokinesis.
Imprinting defects are illustrated by the inability of diploid parthenogenotes to progress through development beyond E10 [ 59].
Inactivation of this protein secretion system in R. l. bv viciae UPM791 led to the inability of the rhizobia to progress beyond the infection zone and the formation of nodules that were unable to fix nitrogen [ 38].
More recently, it has been shown that prostate-specific ablation of FAK in an SV40 T antigen mouse model resulted in the inability of prostate tumours to progress to the aggressive neuroendocrine phenotype [ 13].
The remarkable decrease in mutant L2 protein levels correlates well with the infectivity data (Fig. 5A) and may reflect the inability of these mutant particles to progress past the endo/lysosomal compartment.
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