Perhaps it related to her complete inability to construct a public persona that was anything other than her clumsy, often crude, vulnerable but bafflingly uncrushable self.
What would have been of more concern was their inability to construct decent counter attacking opportunities, particularly before the introduction of Juric.
However their inability to construct a regular, consistent threat on the counter attack, and to create clear goal-scoring opportunities has made it hard to see them coming away with anything but a point.
The inability to construct animal models of human diseases caused by mutated mitochondrial DNA (mtDNA) has been a major obstacle to investigating pathogenetic mechanisms associated with specific mtDNA mutations.
Constructional apraxia, typically caused by a lesion in the right cerebral hemisphere, is the inability to construct elements in the correct fashion to form a meaningful whole e.g., being unable to build a structure with blocks or to copy a design.
Genedirected enzyme prodrug therapy (GDEPT) using adenovirus vectors works well in preclinical models of this disease, but successful clinical application is hampered by an inability to construct vectors that express at high levels in infected tumor cells but not in infected normal cells.
