Sentence examples for inability to bind to from inspiring English sources
And whereas the relatedness to RAS and the inability to bind to RBD mutant p110β argues for binding to the RBD in vitro, the absence of any detectable stimulatory effect on p110β, the limited tissue distribution and growth-inhibitory effects make the role of DIRAS proteins as RBD interactors of p110β in vivo unclear, and further studies will be dedicated to this subject.
In some cases, such as the Grb2 adapter protein GrpL or the phosphodiesterase PDE4A5, an SH3-domain within the substrate is removed causing its inability to bind to physiological interaction partners.
Therefore, we first tested if we could obtain effective and selective inhibition of death receptor-induced apoptosis using FADD-DD and FADD-DD V108E, a mutant that was selected for its inability to bind to Fas, while retaining the ability to bind to TRAIL receptors [28].
The cleaved ADAR2 is now rendered non-functional due to its inability to bind to dsRNA substrates.
Cells treated with BSA, which showed an inability to bind to the cell membrane, were analyzed in the same way as the negative control.
CrkII and CrkL each contain a cSH3 defined by its inability to bind to classic polyproline type II (PPII) motifs (reviewed in [ 31]).
A mutation in AR in the DNA-binding domain resulting in an inability to bind androgens was first reported in a pair of brothers with breast cancer [ 47].
The fungal LICs further differentiate themselves from other small G proteins by their closed P-loops and inability to bind nucleotide, while the metazoan LICs also show an unusual strong preference for binding GDP over GTP.
Gold belongs to the category of metal electrocatalysts for CO2 reduction reaction (CO2RR) producing CO as a major product due to its inability to bind CO.
Furthermore, three major CD-associated mutant of NOD2, 1007fs, R702W, G908R, by virtue of their inability to bind MDP, lose the activity to induce NF-kB ("loss of function"), which is essential for the production of inflammatory cytokines and host responses to invading pathogens.
Normal ductules treated with an estrogen-blocking compound shrunk only 14%, suggesting that the dysfunction of the ERKO ductules is caused at least in part by their inability to bind estrogen.
