A mutation in AR in the DNA-binding domain resulting in an inability to bind androgens was first reported in a pair of brothers with breast cancer [ 47].
The fungal LICs further differentiate themselves from other small G proteins by their closed P-loops and inability to bind nucleotide, while the metazoan LICs also show an unusual strong preference for binding GDP over GTP.
Gold belongs to the category of metal electrocatalysts for CO2 reduction reaction (CO2RR) producing CO as a major product due to its inability to bind CO.
Normal ductules treated with an estrogen-blocking compound shrunk only 14%, suggesting that the dysfunction of the ERKO ductules is caused at least in part by their inability to bind estrogen.
Furthermore, three major CD-associated mutant of NOD2, 1007fs, R702W, G908R, by virtue of their inability to bind MDP, lose the activity to induce NF-kB ("loss of function"), which is essential for the production of inflammatory cytokines and host responses to invading pathogens.
The short linkers, reinforced by novel historic properties, create a number of unique and dynamic nucleosome structural features in vivo: permanent unpeeling of DNA from the ends of the core, an inability to bind even full 147 by core DNA lengths, and facility to undergo a conformational transition that resembles the changes found in active chromatin.
The overall fold of Rv1155 strikingly resembles that of flavin mononucleotide-binding protein and pyridoxamine 5′-phosphate oxydase, but the architecture of the putative binding pocket is markedly different, consistent with the lack of color of Rv1155 and its inability to bind FMN.
This led us to wonder if the inability of the GLS to mediate AD localization was due to its inability to bind the transport machinery tightly.
As noted above, in addition to its inability to bind Cullin (Fig. 2C & 2D), the AN2R protein is non-functional as an E3 ligase in this assay (Fig. 6B).
These 'loukoumasomes' (doughnut-like bodies) bind a monoclonal antibody raised against beta-III-tubulin (SDL.3D10), although their inability to bind other beta-III-tubulin monoclonal antibodies indicate that the responsible antigen is not known.
Thus, the structure suggests that this tetrameric form of the complex would be inhibited for nucleation and processive capping due to an inability to bind actin monomers and filaments.
