The benefits are seen in association with weight reduction in the obese population (1, 2) or without significant weight changes in relatively nonobese population (3, 5).
However, for exenatide, a greater change in A1C and FBG occurred in those with weight loss and for sitagliptin and insulin, greater reductions occurred in those with weight gain.
Dietary or pharmacologic interventions that blunt the decrease in REE with weight loss are in great clinical demand.
To examine differences in breastfeeding frequency, voids, and stools in infants with weight losses < or ≥7% during the postpartum hospitalization.
The risk of islet autoimmunity was greater in subjects with weight z score >0 than in those with weight z score ≤0 over time (2.61 [1.26–5.44], P = 0.01).
In participants with weight gain, lung function declined; whereas in participants with weight loss, lung function increased to a similar extend.
In that material, there was no improvement in BMD with weight bearing.
It has also been described in girls with anorexia nervosa and diabetes in association with weight loss (11).
