Sentence examples for in whim from inspiring English sources

Away from the routine of the home, the hotel guest engages in whim: ordering room-service food that fattens, demanding newspapers that remain unread, traversing oneOs room, nude--luxury.

Carboxy-termini truncating mutations in the chemokine receptor CXCR4 have been identified in WHIM patients.

In WHIM, patients have one normal copy of CXCR4 and a defective copy that causes the receptor to be overactive it doesn't shut off when it's supposed to.

Here, we investigated the biochemical mechanisms underlying CXCR4 deficiency in WHIM syndrome.

G-CSF, which downregulates expression of the CXCR4 receptor and its ligand SDF-1/CXCL12 [24] [26], is commonly used to reduce neutropenia in WHIM patients.

Thus, previous observations support a role for Grk6 as a regulator of CXCR4 function and a mediator of receptor dysfunction in WHIM.

Among the seven known Grks [41], there is circumstantial evidence that Grk6 and Grk3, but not other Grks, may participate in WHIM-associated defective CXCR4 internalization.

These results are consistent with the notion that β-Arrestin 1 and β-Arrestin 2 have independent functions [42], [49], but does not exclude the possibility that β-Arrestin 1 may play some indirect role in WHIM-CXCR4 deficiencies.

We created a retrovirus encoding mutated CXCR4 (truncating point mutation 1000C→T [R334X] inherited heterozygously in several WHIM patients) in order to transducer healthy human CD34 stem cells and K562 to overexpress mutated CXCR4 and determined its effect on receptor responses to stromal-derived factor-1 (SDF1).

CXCR4 has been implicated in different types of cancer [18] [20], in the WHIM (Warts, Hypogammaglobulinemia, Infection and Myelokathexis) syndrome [21], [22], in rheumatoid arthritis [23], and in the immune response during fungal asthma [24].

Instead, she loved the drama's loose ends — details she'd put in on a whim, like a small wind instrument that Frank inexplicably carries in his pocket.