Exact(4)
Dickkopf-1 is implicated in osteolytic diseases, including PDB (Marshall et al, 2009), multiple myeloma (Tian et al, 2003), and rheumatoid arthritis (Diarra et al, 2007), in which it enhances osteoclastic activity by inhibiting bone formation and stimulating its breakdown.
MSC suppresses carcinogen-induced mammary carcinogenesis in rat model [ 3, 4], in which it enhances the fraction of p27Kip1-positive cells in mammary intraductal proliferations [ 5].
Recently, LXRα has also been reported to be atheroprotective by other mechanisms such as in the control of iron homeostasis, in which it enhances iron recycling capabilities by increasing iron release from macrophages [7].
This is interesting in that it fits a pattern observed for DHA in which it enhances the effects of other anti-cancer compounds: 5-fluorouracil on colon cancer cells [ 76], celecoxib on prostate cancer cells [ 77], and doxorubicin [ 78] in breast cancer.
Similar(56)
Further studies should be carried out in order to elucidate the role of melatonin in epigenetic control of gene expression and in the mechanisms by which it enhances the toxicity of chemotherapeutic drugs.
The formation of the trimeric complexes was promoted by ACR, at least in part through which it enhanced the nuclear accumulation of TG2 in a HCC cell line, JHH-7 cells leading to apoptosis.
Although technology has to be managed carefully, there are so many ways in which it can enhance our working lives if we set appropriate boundaries.
The recombinant human NRG1 has been used in clinical trials to treat chronic heart failure in China and Australia (ClinicalTrials.gov identifiers NCT01131637, NCT01258387), in which it proved to enhance heart function and reverse remodeling.
By contrast, LA exhibits dual effects in which it scavenges ROS and enhances the expression of endogenous antioxidant enzymes (Smith et al., 2004).
Thus, there is unlikely to be a single preferred gene therapy for all clinical settings in which it is necessary to enhance osteogenesis.
Most movie music is dull to listen to on its own, no matter how well it enhances the film in which it's deployed.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com