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The principal analyses maintain the subdivisions between continuous-dosing protocols (in which dosing was maintained at a given rate for a defined period) versus discrete-dosing experiments (in which only a single dose, or up to four single doses were given to the animals at defined ages).
Much the same effect was seen in a second experiment, in which dosing did not start until the mice were middle-aged, except that cataracts that had already formed could not be reversed.
However, this design allowed comparison with single-dose studies in which dosing occurred during the same overall postnatal period.
Lipegfilgrastim doses were based on phase 1 results in which dosing was adjusted based on the body weight of patients.
To assess blinding, we asked participants to guess in which dosing period they had received placebo pills.
For example, current recommendations for HRT discontinuation advocate a gradual cessation in which dosing is tapered over a three to six month period [ 38, 39].
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Fast dissolving technology based on a continuous 'form-fill-freeze' process in which doses deposited in blisters are lyophilized has been the leading technology in ODTs [70].
This study was designed to investigate the effects of diazinon at different doses on pancreas and liver tissues and in which dose level diazinon shows its effects.
To test whether a combination of contingency management and methadone dose increase would promote abstinence from heroin and cocaine, we conducted a randomized controlled trial using a 2 × 3 (dose × contingency) factorial design in which dose assignment was double-blind.
In both European and U.S. regulatory sectors, the preclinical requirements for first-in-human studies are substantially reduced for the situations in which doses are kept low to minimize risk to study participants.
To obtain the optimal walking route to verify the operation of the proposed method, we carried out the simulation experiment in which dose and distance were as decision factors.
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