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This hypothesis is supported by our preliminary investigations in which the combination of Cz and fluconazole has a strong synergistic effect against Cn in vitro and by recent studies in C. albican in which alteration of GlcCer synthesis renders the fungus hypersensitive to fluconazole [30].
Cell differentiation is associated with the functional differentiation of the nucleus, in which alteration of the expression profiles of transcription factors occurs to destine cell fate.
Herein, we report another engineered variant DcrH-Hr, I119H, of the same residue, in which alteration of the coordination sphere generates the capability of H2O2-dependent oxidation of exogenous substrates.
This evidence is strongly supported by biochemical studies in L. cuprina in which alteration in the acyl pocket of the active site also confers resistance to dimethyl OPs [ 20].
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The proposed mechanism in which alterations in CP bias alter translation efficiency and it is this that inhibits virus replication introduces a conceptual model in which it is the virus that is intrinsically defective.
The Commission will hold a public hearing on 1 December, in which alterations to the property will be discussed.
This work stems from a previous study in which alterations in the task-negative default mode network were investigated.
In theory, culture-bound syndromes are those folk illnesses in which alterations of behaviour and experience figure prominently, relative to local norms.
The changes in body shape and size associated with pregnancy suggest that pregnancy-related lumbopelvic pain might be a problem in which alterations in body-image are particularly relevant.
It is now considered a multi-factorial and multi-systemic disorder in which alterations of the crosstalk between neuronal and non-neuronal cell types might influence the course of the disease.
To understand the structural role of P0 in myelin membrane adhesion and its mechanism of action, a model system should be developed in which alterations in P0 can be engineered and introduced transgenically into an animal, and in which ramifications across the hierarchy of myelin development, nerve function, and myelin membrane structure and interactions can be determined.
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