Sentence examples for in which activating from inspiring English sources

DAP12 is able to stimulate cytotoxic activity as it contains an immunoreceptor tyrosine-based activation motif and is the mode in which activating KIRs have an effect.

Finally, the reversal in the roles of Rac1 and RhoA in the regulation of NHE1 activity and motility observed here might explain some seemingly contradictory reports in which activating RhoA can lead to either increased or decreased motility and invasiveness [ 18].

* Resolves an issue in which activating an application from the Dock switches to a different space, even if there is a window for that application in the current space.

Thus, our TLX1 mouse model joins other T-ALL mouse models in which activating NOTCH mutations occur spontaneously.

The clearest example is T-cell acute lymphoblastic leukemia/lymphoma (T-ALL, see below), in which activating mutations in the NRR and/or the PEST domain of Notch1 are found in over 50% of cases.

Tumors for which inhibition of Notch signaling may be particularly desirable include breast cancer, where high levels of Notch1 signaling are associated with poorer prognosis [28], [31], and T-ALL, in which activating mutations in Notch1 are found frequently and where treatment with Notch pathway inhibitors, such as GSIs, arrests growth [34], [40], [41].

One hypothesis to explain this process is a diffusion trap in which activated STIM1 diffusing in the ER becomes trapped at junctions through interactions with the PM, and STIM1 then traps Orai1 in the PM through binding of its calcium release-activated calcium activation domain.

Our studies indicate a sequence of events in which activated RhoA by binding to peroxisomes detaches the organelles from microtubules.

Inhibitory mechanisms for TH phosphorylation have been described in striatal neurons in which activated D2-receptors resulted in a reduction of Ser40 phosphorylation of TH [41].

When similar experiments were performed in which activated DUC18 T cells were transferred into antigen-negative Meth A tumor-bearing mice, no lysis of labeled, i.t.

More recently, the use of transgenic mice in which activated CD8+ T cells are tagged utilizing the Cre/lox strategy [3], [4], has allowed characterization of activated CD8+ T cells.