Sentence examples for in vivo evolution from inspiring English sources

We previously modeled the in vivo evolution of human immunodeficiency virus-1 (HIV-1) under drug selective pressure from cross-sectional viral sequences.

In vivo evolution enabled the effective reduction of S/MAR size from 2 kb to 733 bp (resulting in a minicircle of ∼ 3 kb) with largely improved stability and cloning capacity.

The evolved variant performed better in E. coli than in human cells, suggesting optimal usefulness in bacterial rather than viral GDEPT vectors, and highlighting the influence of intracellular environs on enzyme function and the shaping of promiscuous enzyme activities within the "black box" of in vivo evolution.

The impact of the neutralizing antibody response in the in vivo evolution of the HIV-2 Env is currently unknown.

Subjects S2 and S4 harbored X4 variants both in PBMCs and the thymus, and were selected for an in depth study of in vivo evolution of R5 and X4 quasispecies.

The role of selection and random genetic drift in the in vivo evolution of HIV-1 envelope and in the emergence of CXCR4 variants associated with rapid disease progression has been debated for some time with some evidence supporting each model [3], [49], [50].

To improve the performance of existing ZFN technology, we developed an in vivo evolution-based approach to improve the efficacy of the FokI cleavage domain (FCD).

Due to intactness of mRNA, this type of in vitro DNA virus will take the next step toward in vitro autonomous evolution, just like in vivo viral evolution in a cellstat.

Here we review recent phage-based selection systems for in vivo directed evolution.

Conventional in vivo directed evolution methods have primarily linked the biomolecule's activity to bacterial cell growth.

To address this need, we applied in vivo directed evolution to engineer potent retrograde functionality into the capsid of adeno-associated virus (AAV), a vector that has shown promise in neuroscience research and the clinic.