Sequential sampling of blood for molecular changes in blood tumour DNA may be a convenient means of monitoring the in vivo development of tumour resistance mechanisms.
Analysis performed on in vivo development showed a reduced competence of MT embryos to develop up to the blastocyst stage (Table 1).
Kidney rudiments developing in conventional organ culture show excellent recapitulation of in vivo development at a fine scale but one important large-scale aspect of development is typically lost, or at least seriously under-developed.
In control XY gonads, SOX9 was almost entirely nuclear and restricted to the Sertoli cells of the developing testis, consistent with its distribution seen during normal in vivo development [ 25] (Figs. 4a and 4b).
Some differences were also noted in vivo development.
In this paper, we present a first generation computational model for describing the in vivo development of a tissue engineered vein from an implanted polymeric scaffold.
Self-organizing three-dimensional (3D) tissue engineering has been established within the past decade and enables researchers to obtain tissues and cells that almost mimic in vivo development.
Rabbit blastocysts cryopreserved using a 25GLY:25EG solution in mOPS showed a similar rate of in vivo development after thawing to that shown by fresh embryos.
Likewise, to the best of our knowledge, these calves are the first calves derived from full in vivo development of immature slaughterhouse derived oocytes.
Primary cultures of cerebellar granule cells showed a temporal pattern of Lot1 expression resembling that of in vivo development, with mRNA and protein levels progressively decreasing with differentiation.
Thus it is critically important to have thorough characterization of the in vitro organoid system with regard to the extent of recapitulation of in vivo development before it is used for biomedical research and therapeutics.
