Sentence examples for in vitro proof from inspiring English sources

CPP's ability to inhibit ABO incompatibility in vitro, proof of concept in vivo inhibitory activity in rats and the development of the highly potent PA derivative set the stage for preclinical testing of this molecule in small animal models of complement-mediated disease.

As the first in vitro proof of concept, these results indicate that the immunomodulatory properties of H-1PV are not disrupted by chemotherapeutic/targeted agents.

The strong increase in the steepness of the interaction curves going from WT via the second mutant generation to the third mutant generation is a clear in vitro proof of principle of our engineering method (see Figure 1).

We then establish in vitro proof of principle that luminol can be used as a powerful molecular inducer of intracellular CL for the destruction of leukemic cells, overcoming the need of external light sources in PDT.

In vitro proof-of-concept was obtained for healthy donor as well as for DMD patient-derived muscle cells and resulted in novel dystrophin expression.

In this in vitro proof-of-concept study, a converging chemical strategy was used to synthesize the 5-ALA-SQ building block from squalene and 5-ALA.

In vitro proof-of-concept studies revealed that ZnPP encapsulated in PBCAE micelles suppressed HO-1 to make cancer cells more vulnerable to BCA-induced ROS, leading to enhanced apoptotic cell death.

These antiviral vectors provided up to a 10,000-fold reduction in viral titers shed, demonstrating in vitro proof-of-concept for using these novel anti-AIV vectors to inhibit AIV shedding.

This work was necessary and provided in vitro proof-of-concept demonstrating both successful delivery and the antiviral potential of these novel anti-AIV vectors against AIV in an avian cell model.

We designed tkRNAi vectors (anti-AIV vectors) that constitutively generate shRNAs targeting conserved sequences within the NP and PA viral genes, with the purpose to demonstrate in vitro proof-of-concept for using these anti-AIV vectors to inhibit AIV shedding in an avian cell model.

These data suggest that STAT3 is a corepressor with NF- κB of the GADD45G gene and provides in vitro proof-of-concept for the combination of HDACi with SIRT1 activators as a potential new therapeutic strategy in lymphoid malignancies.