Sentence examples for in vitro profiling from inspiring English sources

It is envisaged that such research may lead to the design of reliable in vitro profiling tests for risk assessment and treatment decisions, thereby revolutionizing the practice of medicine with nanopharmaceuticals.

In vitro profiling of compounds promises to provide information on molecular mechanisms of toxicity, and may allow the creation of algorithms for predictive in vivo toxicology.

Consistent with this notion, our (in vivo) spacer sequence experiments show that the I-TevI linker can tolerate substantial variation in the DNA spacer, consistent with previous in vitro profiling (Bryk et al. 1993).

A model connecting ErbB receptor family signaling to cell growth was parameterized using in vitro profiling data, and in silico screening was then performed to identify synergistic drug combinations and predictive biomarkers.

In the current report, we focused on the in vitro profiling of 3Y1 cell lines transfected with MUC1-CD compared with mock-transfected cells to define "intrinsic" MUC1-CD-dependent transcriptional changes without stromal effects.

There have been multiple short-term studies of in vitro profiling after estrogen treatment, predominantly in MCF-7 cells [ 41, 42] and also in ZR-75-1 cells [ 4, 10].

In-vitro profiling showed that CIS22a bound significantly (>50% inhibition at 10 µM) to 12 targets of the 24 selected targets (Fig. 5b).

Multiple potent GRAs were identified with excellent in vitro profiles and good pharmacokinetics in rat.

The in vitro profile, structure, and first synthesis of this indigoid component is reported.

A similar in vitro profile for drug release from NLC containing Precirol ATO 5 was also reported previously [29, 35] (Fig. 4).

Both AT1S and AT2S exhibited a pansomatostatin-like in vitro profile, binding to all five sst1-5 with affinities in the lower nanomolar range.