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The evaluations should also be read in conjunction with other published information regarding the in vitro performance, stability and costs of the tests, including the WHO FIND report (WHO 2012).
An IVIVC describes the relationship between the in vitro performance (e.g., dissolution) and the in vivo characteristics (e.g., plasma drug concentrations or derived pharmacokinetic parameters such as Cmax or area under the curve, AUC) following administration of the dosage form.
In vitro performance tests were performed at a target pressure drop of 4 kPa, using two inspiratory flow ramp-up conditions, representing slow and fast ramp-up of airflow, respectively.
We performed an in vitro performance evaluation of an implantable, bio-resorbable device that supplies short-term controlled release of ciprofloxacin-HCl (CIP).
The in vitro performance of NSCs seeded on nano-fibrous scaffold is addressed in this study.
In 8 studies, in vitro performance did not correctly predict the relative in vivo performance.
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In this paper, we describe the concept of a novel implantable fiber-optic Turbidity Affinity Sensor (TAS) and report on the findings of its in-vitro performance for continuous glucose monitoring.
In this study, a systematic approach was employed to understand the preparation and in-vitro performance of respirable nanoparticle agglomerates by coupling wet milling and spray drying for ibuprofen, which is a drug with a low melting point and challenging mechanical properties.
This study demonstrates the successful preparation of respirable nanoparticle agglomerates of low melting point and ductile ibuprofen and the usefulness of the design of experiments as a tool to understand the impact of the formulation parameters on their fabrication and in-vitro performance.
The authors noted that good in-vitro performance would not always correlate to good performance in-vivo, and poor in-vitro performance is indicative of potential complications.
We proposed that the results of in-vitro performance testing of the cannulae would be associated with preference after clinical comparison.
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