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The increase of PR-positive GECs in the 3D cell culture system upon treatment with 15 pg/mL E is comparable to the increase of PR expression during proestus/early oestrus, and the decline of PR expression in SCs with 30 pg/mL E in vitro mirrors the effects during early metestrus in vivo.
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The splicing patterns observed in vitro mirrored those detected in available patient's tissues [8,13,20].
Interestingly, wild-type cells "loaded" with cholesterol in vitro mirror the fusion defects observed in LSD cells.
Since we expected that our in vitro system mirrors the in vivo situation, we constructed an altered version of the TCRβwt minilocus in which we replaced the Dβ1 23RSS by the Vβ14 23RSS and the Jβ1.2 12RSS by the Dβ1 12RSS, this yielded the TCRβDMF minilocus (Figure 6A).
Under conditions that induced the highest levels of cAMP, the physiology of engineered microvessels in vitro quantitatively mirrored that of native vessels in vivo.
However, the extent to which such in vitro studies mirror the in vivo situation can always be questioned.
Importantly, the levels of invasion indicated by our in vitro assays mirrored the reported abilities of the cell lines to form peritoneal tumours in vivo (Shaw et al, 2004).
Currently, there is no in vitro system that mirrors the complex functions of the human liver.
Second, ex vivo analysis is performed on complex samples including epithelial and immune cells, whereas the in vitro model only mirrors the direct interaction of H. pylori to epithelial-derived AGS cells.
As an in vitro system which mirrors both proliferation and differentiation, the EST proved in an international European Centre for the Validation of Alternative Methods (ECVAM) validation study to be a reliable assay for the prediction of embryotoxicity in vivo (Genschow et al. 2004).
These in vitro findings were mirrored in vivo as expression of two major cytoprotective enzymes were variably elevated in different organs, in two murine models of SCD (Figure 5, 6, 7).
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CEO of Professional Science Editing for Scientists @ prosciediting.com