Sentence examples for in vitro discovery from inspiring English sources

The combination drugs currently employed are primarily of rational design, but the increased efficacy they provide justifies in vitro discovery efforts for identifying novel multi-target mechanisms.

Efficient in vitro discovery methods allowed assignment of R gene-derived SNPs to genomic locations, revealing coincidence with pathogen resistance QTLs in ryegrasses, as well as comparative relationships with other grass and cereal species.

One was the use of closely related breast cancer cell lines with and without an intact tumor-suppressive response so that TGF-β-regulated genes that were specifically involved in tumor suppression could be readily identified, and the other was the coupling of the in vitro discovery steps with in vivo validation.

These models will enable patient-specific prediction of therapeutic and toxic drug responses and drug resistance mechanisms, improve translation of in vitro discoveries to patients, and enhance discovery of pharmacodynamic biomarkers.

Cxcl10 has also been shown to increase the production and activity of gelatinases in RA FLSs [ 61], underscoring the direct relevance of our in vitro discoveries to human disease.

The effects of SLCO1B1 polymorphisms on transporter activity for selected OATP substrates and human PK have been established in both in vitro and in vivo studies; however, a mechanistic model describing these behaviors and connecting in vitro discoveries with in vivo observations has not been developed previously.

In the late 1980s, the National Cancer Institute (NCI) developed an in vitro drug discovery tool to test new therapeutics using 60 different human cancer cell lines [ 4].

SNPs are very amenable to high-throughput analysis but in vitro SNP discovery can be a lengthy and expensive process.

Sixty-five distinct R gene templates were subjected to in vitro SNP discovery through resequencing from parental genotypes of the F1 NA6 × AU6) mapping population.

The main limitation of traditional in vitro drug discovery approaches is that only a small number of compounds are generally confirmed in further in vivo studies, typically owing to inefficacy and toxicity issues.

Using in vivo and in vitro motif discovery analyses, we demonstrate that the IRF5 RelA cistrome is best explained by the presence of consensus NF-κB and noncanonical composite PU.1 interferon-stimulated resPU.1 interferon-stimulatedng sites.