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Further support to this view comes from in vitro demonstrations that Dnmt1 preferentially methylates hemimethylated DNA [8].
Although it is well known that in vitro demonstrations of allelopathic activity of a chemical can rarely be applied to field situation, the most recent studies published in high profile journals [5], [14], [16], [17], [39] still based their conclusions on in vitro experiments.
This is further supported by in vitro demonstrations that chlamydia easily and rapidly develops resistance after serial passage in sub-inhibitory concentrations of macrolides [ 31].
Support for free radical formation has come from in vivo and in vitro demonstrations of stimulation of lipoperoxidation of polyenoic fatty acids by halothane.
Planned comparisons are based on testing a specific hypothesis that centers around a defined set of gene families and rests on known, validated outcomes from prior work, in this case involving both in vivo and in vitro demonstrations of oxidative stress from the organophosphates.
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The in-vitro demonstrations of such networks have been shown by Penchovsky and Breaker [15] and Stojanovic et al. [23].
Our in vitro demonstration that engineered APCs target and kill antigen-specific T cells represents a promising novel strategy for specific immunotherapy of MG and other autoimmune diseases.
The in vitro demonstration of PF4/hep antibodies using functional and immunological methods is essential for optimal management of patients suspected to have HIT.
For in vitro demonstration of the platforms as a potential drug-screening system, A172 glioblastoma cells were cultured and transferred into the 24-well arrays.
Molecular engineering techniques to modify these microbial proteins and encode them in viral vectors has allowed for the introduction of these opsin genes into mammalian cells, with the first in vitro demonstration using mammalian neurons in 2005 [39].
We have established two growth plate-derived chondrocyte cell lines, MMR14 and MMR17, from p53−/− mice (Nakamata T, Aoyama T, Okamoto T, Hosaka T, Nishijo K, Nakayama T, et al. In vitro demonstration of cell-to-cell interaction in growth plate cartilage using chondrocytes established from p53−/− mice. J Bone Miner Res 2003 18 97 107).
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