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In vitro combinations of 9 with ART showed strong synergy against PfINDO (ΣFIC50: 0.31–0.72) but additive to slight antagonistic effects (ΣFIC50: 1.97–2.64) against Pf3D7.
These data demonstrate favorable in vitro combinations of broadly neutralizing HIV-1 MAbs and suggest that such combinations could have utility for HIV-1 prevention and treatment.Over the last 5 years, numerous broadly reactive HIV-1-neutralizing MAbs have been isolated from B cells of HIV-1-infected donors.
In vitro, combinations of V3 substitutions can lead to major loss of entry fitness or even lethality unless compensated by mutations in or near V1-V2 [51], [51].
Combinatorial indices (CIs) were calculated CI<1 (synergy), CI>1 (antagonism) and CI=1 (additive) for in vitro combinations.
Studies have shown that non-synergestic in vitro combinations have been associated with successful therapeutic outcomes [ 3, 5].
combinations of drugs has been proposed as an alternative for oxacillin-resistant staphylococci infections, however, limited information about in vitro combinations are available for multi-resistant strains.
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In an attempt to further address the mechanisms driving the combination of the two agents we performed an in vitro combination assay looking at the impact of the combining EL102 and docetaxel on cell viability.
Moreover, the in vitro combination of 4EDMAB and pleconaril resulted in synergistic antiviral effect.
The in vitro combination phototherapy effect (PDT/PTT) of the nanoplatform ([Pc] = 1.0 4.0 μg/mL and [LOGr] = 1.8 7.0 μg/mL) towards LHRH-positive A2780/AD ovarian cancer cells has been demonstrated using a single wavelength (laser diode irradiation at 690 nm, 0.3 W/cm2 for 15 min) to induce 1O2 generation by Pc and PTT effect by LOGr (Fig. 50).
In 2004, murine tooth structures were successfully bioengineered either after implantation of dissociated rat tooth bud cell-seeded scaffolds in the rat omenta (ectopic site) (Dualibi et al. 2004) or after in vitro combination of non-dental mesenchymal cells with embryonic oral epithelium and transplantation of this primordium into mice adult jaw (Ohazama et al. 2004).
In vitro combination therapy with NO-Cbl on tumor cells in culture exhibited positive effects in inhibiting cell proliferation and decreasing cell survival signaling (Figs. 1 6).
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