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As can be seen in Figure 2A, although the SNU449 and Hep3B cell lines were approximately 80%to90%0% viable after 24 h upon exposure to SGS concentrations of 0.1 to 10 μg/ml, the highest concentration of 100 μg/ml resulted in a drastic drop in viability to 60%and20%0% for SNU449 and Hep3B cells, respectively.
However, induction of dTIP60E431Q using insertion lines B and C caused a reduction in viability to 0% for all three GAL4 drivers while line A reduced viability to approximately 25% for elav-GAL4 (Table 3), 30% for 179y-GAL4, and 40% for 60IIa-GAL4 crosses (data not shown).
To attribute the loss in viability to the measured increase in point mutations, consider the 21-hr data.
There was no effect of 4 μM pazopanib on SK-LMS viability after 3 days, while 32 μM regorafenib was comparable to sorafenib with a cumulative drop in viability to 52.1 ± 3.5% (P < 0.001).
Compared to this, the higher concentration yielded a decrease in viability to about half of the untreated value after irradiation for gold nanoparticles of 15 nm and 30 nm.
As reported previously, a deletion removing the miR-6 cluster, which contains the three miR-6 genes, showed a modest reduction in viability to adulthood (confirmed in Figure 1e).
Similar(54)
The newly synthesized compounds were then tested in viability assays to determine their ability to protect against thapsigargin-induced cell death.
Low concentrations of copper sulfate (1 to 4 mg/L) led to a partly significant increase in viability according to the control treatments.
Reduction of LDHA or PDK1 expression in R7 cells resulted in a 40 to 50% reduction in viability compared to the control cell lines.
For example, IGF1 siRNA in MDA-MB-468 cells led to a 60% reduction in viability compared to NS siRNA control (data not shown).
At 6 and 12 hours, LNCaP cells began to show significant decreases 10-155% decrease) in viability compared to viability of untreated LNCaP cells.
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