The relative efficacy of administering the nitroimidazoles in various schedules ranging from 12 h before to 12 h after BCNU administration also was evaluated.
The efficacy of CBCDA or cisplatin (CDDP) in combination with etoposide has been evaluated in various schedules in other trials in high-grade gliomas with various results (Buckner et al, 1990; Boiardi et al, 1991; Jeremic et al, 1992).
To support MTC traffic, authors proposed in [101] various scheduling schemes by considering channel conditions as well as delay constraints, thus to maximize the number of supported devices per cell.
In addition, there are various scheduling researches addressing a periodic maintenance process.
To achieve full benefit of the systems (e.g., time-division multiplexing (TDM), frequency-division multiplexing (FDM), orthogonal frequency-division multiplexing (OFDM) and OFDMA and make full use of the resources (e.g., power, relays, subchannels), various scheduling problems in various systems have been extensively investigated in recent years [3 23].
In [3] the authors presented the implementation of IEEE 802.15.3 module in ns-2 and discussed various experimental scenario results including various scheduling techniques.
The fact that XR5944 is equally active when administered at 5 mg kg−1, qdx5 schedule as on an intermittent schedule (q7dx3 at 15 mg kg−1) in SCLC (Stewart et al, 2001) and in colon xenografts (data not shown) suggests that it may be possible to use these drugs in combination at various schedules to overcome such side effects.
In ovarian carcinoma, various schedules of peroral administration of etoposide exist that range from 3 to 21 consecutive days of application per cycle, with single daily doses ranging from 25 to 200 mg m−2 and with treatment cycles lasting 2 4 weeks.
IFN-α is the major drug that has been considered for adjuvant therapy and is used with various schedules in Europe, both in stage II and in stage III patients.
Antitumor effects of IL-12 were evaluated in various treatment schedules: intravenous [ 121– 123] versus subcutaneous [ 124, 125] or even intraperitoneal application [ 126], daily and five consecutive injections every 3 weeks [ 121, 122, 127], or at 1 [ 124, 125, 128], 2 [ 123], or 3 [ 129] doses weekly in several-week cycles.
