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Intra-scan differences in uptake time were accounted for by referring all values to a common reference time according to text{BSUV} = text{BSUV}(T_{0}) = text{BSUV}(T) times left(frac{T}{T_{0}}right)^{b},, (1).
First, the correlation might be adversely affected by differences in uptake time (color-coded in the scatter plots) since the time activity curves in liver and blood have different shapes and the LBR, thus, is time-dependent (slowly increasing over time).
Since the difference in uptake time from injection to image acquisition could affect image contrast between the two successive SPECT acquisitions (120 vs 150 min), image acquisition was performed first with the MEGP collimator for five patients and with the HEGP collimator for the remaining five.
Correction for bias due to changes in uptake time.
The algorithm simulatenously accounts for all target lesions and can correct for certain biases (e.g. change in uptake time).
The average difference in uptake time between repeat PET scans was 6 ± 7 min (range 0 – 27 min).
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As an example, we have included a correction for variations in tracer uptake time.
Bias corrections are included to account for variations in tracer uptake time.
Our approach takes into account multiple lesions per-patient and allows for systematic biases such as variation in tracer uptake time.
In particular, uptake (time required for commitment to entry) was relatively rapid (10 to 15 min for half maximum uptake), was greatly decreased at 4°C, and was inhibited by up to 80% by serum.
Other factors potentially resulting in SUV variation or inaccuracy include partial volume effects (in which there is underestimation in small tumours), patient movement between PET and CT, including respiratory motion, and variation in FDG uptake time between initial and restaging PET scans.
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