Apart from B and T cells, T lymphocytes can differentiate into CD8+ or CD4+ T cells, the latter of which can in turn differentiate into Treg and Thelper cells [67].
Neuroblasts in turn differentiate into neurons.
Cell infection with T. cruzi begins with the uptake of infective trypomastigotes within phagosomes and their release into the cytosol, where they are transformed into replicating amastigotes; the latter, in turn, differentiate into trypomastigotes and are released during cytolysis.
Sebaceous glands are formed from a sebocyte progenitor that expresses Blimp 1, keratin 14 (K14) and K5 [29], and these cells produce a proliferative population of sebocytes [30], [32] which in turn differentiate into the lipid/sebum producing cells.
Sebaceous glands extend off of the upper hair follicle and are formed from a sebocyte progenitor that expresses Blimp 1, keratin 14 (K14) and keratin 5 (K5) [29] and these cells produce a proliferative population of sebocytes which in turn differentiate to produce the lipid/sebum producing cells [30].
They, in turn, differentiate into osteoblasts, eventually resulting in ectopic bone formation [ 40].
IL-4 and IL-10 are inducers of M2 phenotype macrophages that help maintain a tolerogenic gut environment and in turn differentiate T helper cells into TH2 [ 82].
Large adipocytes are thought to release more pro-inflammatory cytokines and chemokines that attract circulating monocytes into the WAT which, in turn, differentiate into macrophages [ 5, 28].
They cooperate to establish dorso-ventral polarity, promote proliferation and growth, and trigger mesenchymal condensations, which in turn differentiate into muscles, bones, tendons, and cartilage.
Type A spermatogonia divide to produce further type A spermatogonia (self-proliferation) and intermediate spermatogonia, which in turn differentiate into type B spermatogonia.
